The Don & Cathy Jacobs Science Building houses centrally-scheduled classrooms, numerous chemistry and biology teaching laboratories, and office space for the Department of Chemistry, biology lecturers, and the College of Arts & Sciences Business Center. On the first floor, there is a 300-seat lecture hall; several biology teaching laboratories for physiology, general biology, and microbiology; and multiple technology enabled active learning (TEAL) classrooms; as well as a Shared Imaging Suite and Biology Learning Center.
The second floor houses eight general chemistry teaching laboratories, a 132-seat TEAL room, the General Chemistry Learning Center, and multiple small TEAL rooms. On the 3rd floor, there is a 200-seat lecture hall and multiple upper-level chemistry laboratories, including four organic laboratories and one each of synthetic chemistry, biochemistry, analytical chemistry, and physical chemistry/instrumental analysis.
The 3rd floor also houses the Organic Chemistry Learning Center and a Nuclear Magnetic Resonance (NMR) and Shared Instrumentation Suite to support all the upper-division laboratories, as well as a STEM teaching laboratory.
The exterior courtyard has two outdoor classrooms and natural slate chalkboards with geological features built into the walls. All exterior landscaping contains only native Kentucky plants.