Uk at the Half with Robert Cass
Robert Cass, a mathematics major and the Astronaut Scholarship winner, was the subject of last Saturday’s UK at the Half during the NJIT basketball game.
Sustainability Forum is Dec. 1; Abstracts Due This Friday
The 5th Annual Sustainability Forum, sponsored by the Tracy Farmer Institute for Sustainability and the Environment and the UK Appalachian Center, will take place from 4:30-7 p.m. Tuesday, Dec. 1, at the Hilary J. Boone Center.
UK College of Law, A&S Team Up To Offer 6-Year BA + JD Program
A new collaboration between the University of Kentucky College of Law and College of Arts and Sciences will allow students seeking a law degree to save time and money by graduating in six years instead of seven.
Confucius Institute Presents Lecture on Wu-Wei
The next Distinguished Scholar Lecture presented by University of Kentucky Confucius Institute will examine the spiritual state of wu-wei (effortless action). "Trying Not to Try: Cooperation, Trust and the Paradox of Spontaneity," to be delivered by Canadian researcher and scholar Edward Slingerland,
Racial Conflicts Discussed at UK
Two films highlighting America’s racial conflicts will be shown on the University of Kentucky campus this week, with time scheduled for discussion afterward.
Chemistry Department Seminar
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Dr. Bruce Palfey from the University of Michigan will be presenting a seminar titled: A New Redox State in Flavin Enzymology.
Faculty Host: Anne-Frances Miller
Abstract
Look in a good biochemistry textbook. It will mention three oxidation states for flavins: fully oxidized, one-electron reduced, and two-electron reduced. These redox forms have been studied since before you were born, and account for a huge amount of the chemistry of flavoenzymes; highly unstable covalent adducts to flavins account for the rest. In particular, a plethora of flavin-dependent monooxygenases have been identified. Back in the age of disco and into the Reagan administration, there was a hot debate over the identity of the flavin intermediate that oxygenates organic substrates. The flavin-N5- oxide, known from chemical synthesis, was proposed as the intermediate, but resoundingly rejected - only the flavin-C4a-hydroperoxide was clearly consistent will all experimental evidence. Thus the flavin-N5-oxide was banished from enzymology - until now. The enzyme EncM is part of the enterocin biosynthetic pathway. It uses O2 to
oxygenate a complex polyketide substrate. Years of searching for a flavin-C4a- hydroperoxide oxygenating intermediate were fruitless. Instead, we were shocked - yes, shocked! - to unequivocally identify the flavin-N5-oxide as the species that transferred oxygen to the substrate [1]. This identification rests on mass spectroscopy, isotopic labeling, absorbance spectroscopy, and good old fashioned chemistry [1, 2]. Its discovery leads to a catalytic cycle that is very unusual for a flavoenzyme. With a cool new enzyme intermediate come many questions. What is the mechanism of its formation? What is the mechanism it uses for oxygen-transfer? What kinds of substrates can it oxygenate? Are there any other enzymes that use the flavin-N5-oxide? Etc.
Date:
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Location:
CP 114
LSS Episode 5 - I Voted for Shirley Chisholm
Noted American philosopher Biz Markie once said, "Make you co-op-er-ate with the rhythm, that is what I give 'em/ Reagan is the pres but I voted for Shirley Chisholm." In this episode of Long Story Short, Dara and Cody pull back the curtain on Shirley Chisholm's 1972 Presidential bid and, through her, take a look at what it would take for a woman to become President of the United States.
This podcast was produced by David Cole.
UPK Authors Showcased at Kentucky's Largest Literary Event
Now in its 34th year, the Kentucky Book Fair will be held from 9 a.m. to 4:30 p.m. Saturday, Nov. 14, at the Frankfort Convention Center. This year’s fair will feature more than 200 authors and editors showcasing their most recent books including several writers from University Press of Kentucky (UPK).
Writer/Artist Wayne Koestenbaum to Lecture
The University of Kentucky's Art Museum and MFA (Master of Fine Arts) Creative Writing Program in the Department of English welcomes to campus essayist, poet, artist and cultural critic Wayne Koestenbaum to discuss his paintings and writings with UK Art Museum Director Stuart Horodner at 6:30 p.m. Friday, Nov. 13, in 106 Whitehall Classroom Building.