Affiliation: Rice University

Research: https://lrg.rice.edu/

Abstract: Recent efforts by our group and others have shown the promise of applying single molecule methods to link mechanistic detail about protein adsorption to macroscale observables. When we study one molecule at a time, we eliminate ensemble averaging, thereby accessing underlying heterogeneity. However, we must develop new methods to increase information content in the resulting low density and low signal-to-noise data and to improve space and time resolution. 

I will highlight recent advances in super-resolution microscopy for quantifying the physics and chemistry that occur between target proteins and stationary phase supports during chromatographic separations. My discussion will concentrate on the newfound ability of super-resolved single protein spectroscopy to inform theoretical parameters via quantification of adsorption-desorption dynamics, protein unfolding, and nano-confined transport. Additionally, I will discuss using phase manipulation to encode temporal and 3D spatial information, and the opportunities and challenges associated with such imaging methods.

The Dimensions of Political Ecology Conference (DOPE) is organized and hosted entirely by an interdisciplinary group of graduate and undergraduate students at the University of Kentucky. Since its inception in 2010, this student-organized conference has become one of the largest, most highly regarded international forums for critical discussions at the intersection of ecology, political economy, and science studies. DOPE 2020 welcomes Dr. Alaka Wali, Dr. Diana Ojeda, Dr. Justin Dunnavant, Dr. Macarena Gómez-Barris, and Dr. Rebecca Elmhirst as our speakers, along with many professors, graduate students, and undergraduate students. The DOPE Conference offers a platform for both established and emerging scholars to present research and engage in political ecology scholarship. Registration is free for UK graduate and undergraduate students! Register here!