Abstract: Recent research has revealed the essential role that microbial metabolites play in host-microbiome interactions. Although statistical and machine-learning methods have been employed to explore microbiome-metabolome interactions in multiview microbiome studies, most of these approaches focus solely on the prediction of microbial metabolites, which lacks biological interpretation. Additionally, existing methods face limitations in either prediction or inference due to small sample sizes and highly correlated microbes and metabolites. To overcome these limitations, we present a transfer-learning method that evaluates microbiome-metabolome interactions. Our approach efficiently utilizes information from comparable metabolites obtained through external databases or data-driven methods, resulting in more precise predictions of microbial metabolites and identification of essential microbes involved in each microbial metabolite. Our numerical studies demonstrate that our method enables a deeper understanding of the mechanism of host-microbiome interactions and establishes a statistical basis for potential microbiome-based therapies for various human diseases.

Second year MFA students who will be graduating in May will read from their theses.

Abstract: The exceptional ability of crystalline lattices to alter electronic properties  brought about the semiconductor electronics revolution and continues to surprise us. Recently, electrons in artificial moiré lattices have emerged as an extraordinary new platform. The simplest such moire' material consists of a pair of graphene sheets twisted relative to one another. At a  "magic" twist angle of about 1 degree, a variety of interesting phenomena including superconductivity and zero-field quantum Hall effect are observed. In this talk, I will review this rapidly moving field and describe the new perspectives  it has provided on the geometry of quantum states and the mathematical foundations behind it.  Finally, I will detail how this newfound understanding led us to propose a new class of moiré superconductors,  beginning with twisted trilayer graphene, which is presently under intensive experimental examination.

Coffee and tea will be served in CP 179 starting at 3:30 PM. 

Ashvin Vishwanath is a condensed matter theorist who studies collective phenomena in quantum systems.  His previous research has brought to light new insights and discoveries, including the central role of "hedgehog" defects in phase transitions, the occurrence of distinctive surface states in Weyl semimetals, Dirac fermion dualities and the notion of surface topological order. Presently, his attention is focused on unraveling the mysteries of moiré materials and exploring ways to create highly entangled states in synthetic quantum platforms.



Ashvin was born and raised in Bangalore, India and earned his undergraduate degree in Physics from the Indian Institute of Technology Kanpur. He then moved to Princeton University for his PhD, under Duncan Haldane following which he held a Pappalardo postdoctoral fellowship at MIT and then moved on to a faculty position at the University of California, Berkeley.  He spent twelve years on the faculty at UC Berkeley, before moving to his current position  in 2016 as Professor of Physics at Harvard University. He is also the Director of the Simons Collaboration on Ultra Quantum Matter,  He has been awarded the  Sloan and Guggenheim Fellowships, the 2016 Europhysics Prize, and was elected to the American Academy of Arts and Sciences in 2021.

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The van Winter Memorial Lecture is an annual lecture sponsored jointly by the Department of Mathematics and the Department of Physics and Astronomy.  It honors the memory of Clasine van Winter, who held a professorship in the Departments of Mathematics and of Physics and Astronomy from 1968 until her retirement in 1999. Professor Van Winter specialized in the study of multiparticle quantum systems; her contributions include the Weinberg-van Winter equations for a multiparticle quantum system and the so-called HVZ Theorem which characterizes the essential spectrum of multiparticle quantum systems. She passed away in October of 2000.    A list of past van Winter Lectures is available here.